The Vampire Drusilla from Buffy the Vampire Slayer, created by Joss Whedon and portrayed by Juliett Landau, is one of my favorite vampire characters ever envisioned in any media form. Drusilla is completely and utterly crazy, which is one of the main reasons she is so very dear to my heart as a character.
She speaks with a sing-song cockney accent that belies her origin, talking in rambling nonsensical non-sequitors that have layers of nuance and meaning to those capable of wading through her madness. Beyond being simply a mad vampire (a terrifying concept in-and-of itself) Drusilla is a psychic attuned to some 'higher source' and capable of making prophecy and experiencing precognitive visions.
As a human in 1860's London, Drusilla viewed her psychic ability as an unholy curse, fleeing to a catholic nunnery out of desperation. Unfortunately, this action brought her to the attention of the vampire Angelus, who became immediately enthralled with the girls purity and abilities. It became Angelus' driving goal to shove the young girl into madness and destroy her potential for goodness.
To this end, Angelus hunted down and tortured her entire family. Even as she fled to a convent in Prauge, she was pursued by this dark suitor, relentless in his machinations. On the day she was to take her vows, Angelus slaughtered everyone in the convent before her eyes, forcing her to watch each death and all the while while engaging in perverse fornication with his own sire Darla. As madness consumed the poor girl, Angelus took pride in this creation, viewing her as his masterpiece and embracing her as a vampire to preserve his work.
As a vampire, Drusilla from Buffy the Vampire Slayers TV Show, had a capacity for evil that impressed even the worst of the undead. When she took the poet William the Bloody, later renamed Spike, as her companion, the two created an unholy union whose shock-wave reverberated across continents. Together, they were instrumental in scenes of atrocity throughout the world, including the Boxer Rebellion where Spike killed his first Slayer, finally arriving in Sunnydale, CA in the late 1990s with the goal of killing Buffy Summers, the world’s current Slayer.
While she embodies a girlish and waif-like appearance and aura about her, Drusilla from Buffy is hundreds of years old, strong, creative, and extremely dangerous, an attribute enhanced by her volatile madness. Her psychic abilities allow her to escape many situations that would be final death for many others, and grants her a hypnotic aura shared by few other vampires. She employed this power to kill the Slayer Kendra at the culmination of season two, a feat few other vampires can boast.
Drusilla is one of the few vampires in the Buffy universe who survived throughout the show, and the spin-off Angel
"The world changes, we do not, there lies the irony that finally kills us." -- Armand, Interview with the Vampire